Evening Ebola Update, Tues, 11/4: mAb drugs act on current ZEBOV; LIJ EBOV manual on-line   Leave a comment

11/04/14

Dear Colleagues:

l.  CDC’s Morbidity and Mortality Weekly, Vol. #63, reports today on community treatment centers (CTC) set up in rural areas of Liberia to isolate confirmed EBOV patients and suspected EBOV patients from other villagers prior to their transfer to Ebola treatment centers which Liberia is building in each of its 15 provinces.  CTCs successfully isolate patients; staffing is helped by families which bring food to feed patients (if they are able to eat).  Confirmed EBOV patients and suspected EBOV patients are in separate tents in the CTC, and movement of staff, provisions, and medicines is one way only: from possible EBOV patient tent to confirmed EBOV patient tent.  See: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm63e1104a1.htm?s_cid=mm63e1104a1_e for complete story in M&M.

2.  PLoS Currents Outbreaks published on-line today an article by Ponomarenko, et. al. examining the segments of glycoprotein (segments are called epitopes) on the current Zaire EBOV to which monoclonal antibodies (mAb) in experimental drugs such as ZMapp attach.  These epitopes were compared with epitopes of glycoproteins from previous Zaire EBOV outbreaks in 1976 and 1995.  The authors found that the current Zaire EBOV epitopes resemble closely the prior Zaire EBOV epitopes.  That’s good news for experimental drugs which used the 1976 and 1995 Zaire EBOV genome to develop their monoclonal antibodies.  However, the glycoprotein of Zaire EBOV does not resemble the glycoprotein of other EBOV strains (this is known as low conservancy) so drugs and vaccines designed for Zaire EBOV may not be effective against other strains of EBOV.  See: http://currents.plos.org/outbreaks/article/obk-14-0050-conservancy-of-mab-epitopes-in-ebolavirus-glycoproteins-of-previous-and-2014-outbreaks/ for complete article.

3.  North Shore Long Island Hospital has prepared an EBOV treatment manual for clinicians which is available on-line.  Complete the following short sign-on to receive the manual on line: http://www.nslijalerts.com/homepage/ebola-virus/for-healthcare-organizations/north-shore-lij-ebola-virus-preparedness-manual/?utm_source=pr&utm_medium=bitly&utm_campaign=ebola-pr-bitly

RGL, MD

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Posted November 5, 2014 by levittrg in Ebola

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