Evening Ebola Update, Sun, 12/7: 10th physician dies/GBV-C infection may improve survival   Leave a comment

12/7/14:

Dear Colleagues:  Today is Sunday in the U.S; Sunday is the second day of rest in our Saturday/Sunday weekend.  EBOV reports from the news media and Web are decreased on the weekends.  But there is some news to report:

l. Al Jazeera reports that a 10th physician in Sierra Leone has died of EBOV.  Only 1 Sierra Leone physician with EBOV has survived his disease.

2.  Journal of Virology 3 December has an article by Lauck, et. al. from Pathology at the University of Wisconsin-Madison reporting that 13 of 49 patients with EBOV in Sierra Leone also had the pegivirus GBV-C.  These patients with GBV-C had a 50+% survival rate, while patients without GBV-C had a 20+% survival rate.  Patients between the ages of 21-45 years had the highest rate of GBV-C.  In HIV disease GBV-C decreases the pathogenicity of HIV by decreasing the immune response.  Perhaps GBV-C has the same action in EBOV.  Alternatively, the improved survival rate of EBOV patients with GBV-C may be due to their intermediate age (21-45 years).  See the article at: http://jvi.asm.org/content/early/2014/11/27/JVI.02752-14.full.pdf+html

RGL, MD

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Posted December 7, 2014 by levittrg in Ebola

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