Evening Ebola Update, Sun, 12/14/14: Senior at Kenyon has clear EBOV review/Dr. Lai on need for universal influenza vaccine   Leave a comment

12/14/14

Dear Colleagues:

Today is Sunday in the U.S.  Sunday is a day off work/day of rest for media writers and journal staffs.  So my web sources are ‘quiet’ today.  I do want to post an interesting review of EBOV from a senior at Kenyon College in 2010 because the review is clearly written and contains many colorful illustrations which I found useful to understand concepts.

I also want to post an article on the need for a universal vaccine against influenza (‘universal’ meaning directed against the nonstructural (NS) protein of influenza)) to prevent a pandemic from a highly pathogenic, highly transmissible influenza virus in the future.  (A NS protein is a protein encoded by a virus which is not ‘packaged’ inside the mature virus particle).

l.  MicrobeWiki published on-line in 2010 a review by Keith Miller, M.D., then a senior at Kenyon College.  The author writes very clearly so that the immunology of EBOV known in 2010 is understandable.  See the review at: https://microbewiki.kenyon.edu/index.php/Infection_Mechanism_of_Genus_Ebolavirus.  The roles of GP, sGP and ssGP have been further elucidated since Miller’s review.

2.  Dr. Lai has published an article on why some influenza pandemics are more deadly than others.  This article emphasizes the role of the nonstructural protein NS1 produced by influenza virus genome in determining the case mortality of a particular influenza pandemic.  His Figure 2 in the article at: http://www.jidc.org/index.php/journal/index illustrates why the Spanish Flu and certain later pandemics were so deadly.

RGL, MD

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Posted December 15, 2014 by levittrg in Ebola

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