Evening Ebola Update, Wed, 1/14: Vaccine testing back on track/Beware of MERS-CoV in S.A./ Modelling with determine EBOV vaccine testing sites   Leave a comment

1/14/15

Dear Colleagues:  This week’s issue of The Lancet has three very good articles on the plan for various EBOV vaccines and other therapies for the first quarter of 2015:

l.  The Lancet 14 January has a Personal View by Tulley, et. al. from the Jenner Institute at Oxford University describing how the world has joined together in international consortiums to produce and test EBOV vaccines like never before.  Vaccine experiments, production, and testing has moved at ‘warp speed’ (from ‘Star Trek’) c/w previous vaccine development.  The authors outline which vaccine will be tested when in 2015 and how the vaccines differ in structure.  See this article at: http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(14)71071-0/fulltex

2.  The Lancet 13 January has a World View by Mohammadi of The Lancet on how the vaccines got ‘back on track’ to be tested in Phase 3 trials in West Africa.  Computer modelling will be used to determine the sites of testing because the number of new EBOV cases is decreasing.  This article is complementary to Tully, et.al.  See the article at: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60035-6/fulltext

3.  The Lancet 13 January has a Comment by Zumla, et. al. from University College London telling us to beware of MERS-CoV which is clustered in Saudi Arabia.  The current MERS-CoV outbreak has similarities to the current EBOV epidemic; many questions about origin, transmission, intermediate hosts, treatment are unanswered and MERS-CoV has a 37% case mortality rate.  The authors say we should focus on MERS-CoV which is in the ‘shadow of EBOV’ and respond to the MERS-CoV outbreak in the manner we plan to respond to EBOV in 2015.  See the article at: http://www.thelancet.com/journals/lanres/article/PIIS2213-2600(14)70316-9/fulltext

RGL, MD

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Posted January 15, 2015 by levittrg in Ebola

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