Evening Ebola Update, Wed, 1/28: Interactive EBOV Case in NEJM/ChAd3 vaccine safe and active/’Weekend’ hospital staffing   Leave a comment

1/28/15

Dear Colleagues:

This week’s NEJM issue dated 29 January and its on-line companion issue posted today 28 January contain several EBOV related articles.  My blog this evening is devoted to these articles and a touching Perspective on ‘weekend coverage’ at hospitals by a physician/journalist whose mother was hospitalized over a weekend:

1.  By permission, NEJM editors have allowed posting of this week’s Interactive Medical Case: ‘A Liberian Health Care Worker with Fever’ for this blog’s readers.  The Liberian HCW is followed as her diagnosis of EBOV is made, her treatment initiated, her critical period of illness analyzed, and her recovery supported.  The diagnosis process and treatment are based on current data, and the discussions of each stage of her clinical course helpful.  The illustration of the African patient naked in the Physical Exam section is both insensitive and without purpose in my opinion.  No reason she couldn’t be dressed in an examining gown.  See the Interactive Medical Case at: http://www.nejm.org/doi/full/10.1056/NEJMimc1414101?query=TOC

2.  NEJM on-line 28 January has posted an article by Ramping, et. al. from an international consortium re: the safety and immunogenicity of chimpanzee adenovirus encoded with Ebola Zaire glycoprotein (GP) as a monovalent vaccine.  The authors found the ChAd3 (or cAd3) both safe and immunogenic at doses given in 60 U.K. volunteers.  The vaccine will now be Phase 3 tested in Africa.  See the entire report at: http://www.nejm.org/doi/full/10.1056/NEJMoa1411627?query=featured_ebola

3.  NEJM 29 January has a Perspective by Perri Klass, a Professor of Pediatrics and Journalism at NYU, who writes about her mother’s hospitalization over a weekend, including the results of ‘weekend staffing’ at the hospital.  The Perspective is touching and a wake-up call to all of us who will someday be in her mother’s situation- hospitalized over a weekend waiting for Monday to see certain physicians or obtain certain tests or treatments.  See the Perspective at: http://www.nejm.org/doi/full/10.1056/NEJMp1413363?query=TOC

RGL, MD

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Posted January 29, 2015 by levittrg in Ebola

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